Stem Cell Research
Stem Cell Research / iPSCs

Two major scientific papers published in Science and Cell (pdf) unveil a proven way to generate patient-matched human pluripotent stem cells without human cloning, and without the use of human embryos or human or animal eggs. Research groups in Wisconsin and Japan have generated "induced pluripotent state" (iPS) cells with the properties of human embryonic stem cells by direct reprogramming of adult cells.

News

nature piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

Nature, March 1, 2009

Do we still need embryos and cloning?
Answering Common Claims about induced
pluripotent stem cells
59k Adobe Acrobat Document

Stem Cell Vindication -
By Charles Krauthammer
The Washington Post

Stem-Cell Breakthrough
Wall Street Journal

The End of the Stem-Cell Wars
The Weekly Standard

A stem cell 'milestone'
Los Angeles Times , November 20, 2007

Cell News Opens Door To Drug Discovery
Forbes, November 20, 2007

Stem cells without embryos:
skin cells transformed
Reuters, November 20, 2007

New Stem Cell Method Could
Ease Ethical Concerns
The New York Times, November 20, 2007

'Milestone' stem cell advance reported
CNN, November 20, 2007

The Future Is Now
National Review Online , November 20, 2007

Researchers Create Stem Cells Without Destroying Embryos
Wall Street Journal, November 20, 2007

Stem cell breakthrough uses no embryos
Seattle Post-Intelligencer , November 20, 2007

Reprogramming Somatic Cells Towards Pluripotency by Defined Factors
Science, November 2007

Summary of results on induced pluripotent state cells 23k Adobe Acrobat Document



BACKGROUND

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
Nature, June 2007

Directly Reprogrammed Fibroblasts Show Global Epigenetic Remodeling and Widespread Tissue Contribution - Cell Stem Cell, June 2007

A Transcriptional Logic for Nuclear Reprogramming
Cell, August 2006

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors - Cell, August 2006

How Direct Cell Reprogramming Works
Westchester Institute